Consumer Information

Lupron

Generic Name: leuprolide (LOO proe lide)
Brand Names: Eligard, Lupron, Lupron Depot, Lupron Depot-Gyn, Lupron Depot-Ped

What is Lupron?

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Lupron is a man-made form of a hormone that regulates many processes in the body. Lupron overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily. It reduces the amount of testosterone in men or estrogen in women.

Lupron is used in men to treat the symptoms of prostate cancer. Lupron treats only the symptoms of prostate cancer and does not treat the cancer itself. Use any other medications your doctor has prescribed to best treat your condition.

Lupron is used in women to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.

Lupron is also used to treat precocious (early-onset) puberty in both male and female children.

What is the most important information I should know about Lupron?

Lupron can cause birth defects. Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment. You should not use Lupron if you are allergic to leuprolide or similar medications such as buserelin (Suprefact, Suprecor), goserelin (Zoladex), histrelin (Supprelin), nafarelin (Synarel), or if you have abnormal vaginal bleeding that has not been diagnosed by a doctor; or if you are breast-feeding a baby.

Before using Lupron, tell your doctor if you have epilepsy, asthma, migraines, heart or kidney disease, a history of depression, bone cancer affecting your spine, blood in your urine, or if you are unable to urinate.

Tell your doctor if you have a personal or family history of osteoporosis, or if you have any risk factors for bone loss such as smoking, alcohol use, or taking steroid or seizure medications long term. Long-term use of this medication may decrease bone density, possibly leading to osteoporosis.

What should I discuss with my healthcare provider before using Lupron?

Certain brands or strengths of leuprolide are used to treat only men and should not be used in women or children. Always check your medication to make sure you have received the correct brand and strength prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy. You should not use Lupron if you are allergic to leuprolide or similar medications such as buserelin (Suprefact, Suprecor), goserelin (Zoladex), histrelin (Supprelin), nafarelin (Synarel), or if you have:

abnormal vaginal bleeding that has not been diagnosed by a doctor; or
if you are pregnant or breast-feeding.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using Lupron, tell your doctor if you have:

a personal or family history of osteoporosis;
risk factors for bone loss such as smoking, alcohol use, or taking steroid or seizure medications long term;
epilepsy;
asthma;
migraines;
heart disease;
kidney disease;
a history of depression;
bone cancer affecting your spine;
blood in your urine; or
if you are unable to urinate.

FDA pregnancy category X. This medication can cause birth defects. Do not use Lupron if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Lupron usually causes women to stop ovulating or having menstrual periods. However, you may still be able to get pregnant. Use an effective barrier form of birth control (such as a condom or diaphragm with spermicide gel or inserts). Hormonal forms of contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective in preventing pregnancy while you are using Lupron. Because Lupron is expected to cause your menstrual periods to stop, contact your doctor if your periods continue while you are being treated with this medication. Do not breast-feed a baby while using Lupron.

Long-term use of this medication may decrease bone density, possibly leading to osteoporosis. Talk with your doctor about your possible risk for osteoporosis. You may need to receive a bone scan if you ever need to be re-treated with Lupron in the future.

How should I use Lupron?

Lupron is given as an injection under the skin or into a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Lupron may be given once every month or once every 3 to 6 months. How often you receive this medication will depend on the condition being treated. Follow your doctor's instructions.

Because different brands or strengths of leuprolide are used to treat different conditions, it is very important that you receive exactly the brand and strength your doctor has prescribed. If you self-inject this medication at home, always check your medication to make sure you have received the correct brand and type prescribed by your doctor.

Your symptoms may become temporarily worse as your hormones adjust when you first start using this medication. For best results, keep using the medication as instructed by your doctor. Your condition should eventually improve with continued use of Lupron.

To be sure this medication is helping your condition, your blood may need to be tested often. This will help your doctor determine how long to treat you with Lupron. You may still need blood tests for up to 3 months after you stop using Lupron to check your hormone levels and pituitary gland function. Do not miss any scheduled appointments.

Store Lupron in the original carton at room temperature, away from moisture and heat. Store Eligard in the refrigerator. Do not freeze. You may take the medicine out and allow it to reach room temperature before mixing and injecting your dose. After the dose is mixed, you must use the injection within 30 minutes.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose.

Women who miss more than one Lupron dose may have breakthrough bleeding. Children who miss more than one dose may have a return of pubertal symptoms such as breast development, growth in the testicles, or menstrual periods.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include weakness, or irritation where the Lupron shot was given.

What should I avoid while using Lupron?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using Lupron.

Lupron side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

bone pain;
swelling, rapid weight gain;
pain, burning, stinging, bruising, or redness where the medication was injected;
feeling like you might pass out;
painful or difficult urination;
urinating more often than usual; or
sudden headache with vision problems, vomiting, confusion, slow heart rate, weak pulse, fainting, or slow breathing.

Rare but serious side effects may include:

pain or unusual sensations in your back;
numbness, weakness, or tingly feeling in your legs or feet;
muscle weakness or loss of use; and
loss of bowel or bladder control.

Less serious side effects may include:

acne, increased growth of facial hair;
breakthrough bleeding in a female child during the first 2 months of Lupron treatment;
dizziness, weakness, tired feeling;
hot flashes, night sweats, chills, clammy skin;
nausea, diarrhea, constipation, stomach pain;
skin redness, itching, or scaling;
joint or muscle pain;
vaginal itching or discharge
breast swelling or tenderness;
testicle pain;
impotence, loss of interest in sex;
depression, sleep problems (insomnia), memory problems; or
redness, burning, itching, or swelling where the shot was given.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect Lupron?

There may be other drugs that can interact with Lupron. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about Lupron.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.